Anna Moles Selected Research

9- piperazin- 1- ylpyrrolo(2,1- b)benzothiazepine

9/2008

Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine), but not the novel atypical antipsychotic ST2472 (9-piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), chronic administration induces weight gain, hyperphagia, and metabolic dysregulation in mice.

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Anna Moles Research Topics

Disease

7	Liver Cirrhosis (Hepatic Cirrhosis) 11/2021 - 04/2009
6	Liver Diseases (Liver Disease) 01/2022 - 07/2011
6	Fibrosis (Cirrhosis) 01/2019 - 07/2011
5	Body Weight (Weight, Body) 06/2018 - 05/2010
4	Obesity 06/2018 - 09/2010
4	Neoplasms (Cancer) 07/2017 - 11/2014
4	Inflammation (Inflammations) 01/2017 - 04/2009
3	Chronic Renal Insufficiency 01/2019 - 02/2016
2	Neuroblastoma 07/2017 - 06/2013
2	Hyperphagia (Overeating) 06/2013 - 09/2008
2	Dyslipidemias (Dyslipidemia) 09/2010 - 12/2009
2	Weight Gain 07/2010 - 09/2008
1	Hepatocellular Carcinoma (Hepatoma) 11/2021
1	Non-alcoholic Fatty Liver Disease 11/2021
1	Mucopolysaccharidoses 01/2020
1	Feeding and Eating Disorders (Eating Disorder) 06/2018
1	Liver Failure 01/2018
1	Acute Liver Failure (Fulminant Hepatic Failure) 01/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2018
1	Pathologic Processes 01/2017
1	Kidney Diseases (Kidney Disease) 01/2017
1	Alcoholic Fatty Liver 11/2016
1	Reperfusion Injury 02/2016
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Respiratory Hypersensitivity 01/2016
1	Acute Kidney Injury (Acute Renal Failure) 01/2016
1	Rhabdomyosarcoma 11/2014
1	Urticaria (Hives) 01/2013
1	Cicatrix (Scar) 09/2012
1	Hypoxia (Hypoxemia) 03/2012
1	Niemann-Pick Diseases (Niemann Pick Disease) 01/2012
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2012
1	Autistic Disorder (Autism) 01/2011
1	Overweight 07/2010
1	Insulin Resistance 12/2009
1	Glucose Intolerance 12/2009
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2009
1	Hyperinsulinism (Hyperinsulinemia) 12/2009
1	Carcinogenesis 04/2009
1	Pain (Aches) 08/2008

Drug/Important Bio-Agent (IBA)

6	CathepsinsIBA 11/2021 - 04/2009
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2012
4	MicroRNAs (MicroRNA)IBA 07/2017 - 03/2012
4	Antipsychotic Agents (Antipsychotics)IBA 09/2010 - 09/2008
3	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 01/2016
3	Glucose (Dextrose)FDA LinkGeneric 09/2010 - 12/2009
2	LipidsIBA 06/2018 - 01/2013
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2012
2	Cathepsin DIBA 02/2016 - 01/2016
2	pepstatin (pepstatin A)IBA 02/2016 - 01/2016
2	RNA (Ribonucleic Acid)IBA 01/2016 - 01/2013
2	Messenger RNA (mRNA)IBA 01/2016 - 08/2008
2	Pharmaceutical PreparationsIBA 06/2013 - 09/2010
2	Peptides (Polypeptides)IBA 02/2013 - 08/2008
2	antiarrhythmic peptide (AAP)IBA 07/2010 - 12/2009
2	Olanzapine (Zyprexa)FDA Link 12/2009 - 09/2008
1	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 01/2022
1	Heparitin Sulfate (Heparan Sulfate)IBA 01/2019
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2019
1	EnzymesIBA 01/2019
1	NeuropeptidesIBA 06/2018
1	N-acetyl-4-benzoquinoneimine (NAPQI)IBA 01/2018
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2018
1	Sirtuin 1IBA 11/2016
1	Cysteine (L-Cysteine)FDA Link 11/2016
1	Chloroquine (Aralen)FDA LinkGeneric 02/2016
1	Fulvestrant (Faslodex)FDA Link 01/2016
1	glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA 06/2013
1	Bleomycin (Blenoxane)FDA LinkGeneric 06/2013
1	IonomycinIBA 06/2013
1	1- ((fluoro(methyl)phosphoryl)oxy)- 3- isopropoxypropan- 2- yl oleateIBA 06/2013
1	EndocannabinoidsIBA 06/2013
1	LipopolysaccharidesIBA 02/2013
1	Serine (L-Serine)FDA Link 02/2013
1	CarbohydratesIBA 01/2013
1	imidaclopridIBA 01/2013
1	OsteopontinIBA 09/2012
1	Collagen Type I (Type I Collagen)IBA 09/2012
1	Cathepsin BIBA 01/2012
1	AcidsIBA 01/2012
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2012
1	neodymium pyrocatechin disulfonate (NPD)IBA 01/2012
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2012
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2012
1	Type I Tumor Necrosis Factor ReceptorsIBA 07/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2011
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 07/2011
1	Opioid Analgesics (Opioids)IBA 01/2011
1	Carbon Tetrachloride (Tetrachloromethane)IBA 09/2010
1	Insulin (Novolin)FDA Link 09/2010
1	LeptinIBA 09/2010
1	Haloperidol (Haldol)FDA LinkGeneric 07/2010
1	Nonesterified Fatty Acids (NEFA)IBA 05/2010
1	CollagenIBA 04/2009
1	9- piperazin- 1- ylpyrrolo(2,1- b)benzothiazepineIBA 09/2008
1	BenzodiazepinesIBA 09/2008
1	Formaldehyde (Formol)FDA Link 08/2008

Therapy/Procedure

4	Therapeutics 01/2020 - 09/2012
1	Kidney Transplantation 01/2017
1	Ligation 09/2010